Publications: Representative Publications

Publications

83.) Zhang, G.-W.; Ge, H.-B.* Asymmetric C–C bond functionalization. (to be submitted)

82.) Zhang, G.-W.; Ge, H.-B.* Nickel-catalyzed alkyne C–C bond functionalization. (to be submitted)

81.) Yuan, D.; Xu, Z.; Zhou, Y.; Herington, F.; Liu, C.; Yang , K.* Ge, H.-B.* Palladium-Catalyzed Cascade Reactions for Synthesis of Heterocycles initiated by C(sp3)‒H Functionalization. (submitted)

80.) Zhang, G.-W.; Ge, H.-B.* Palladium-catalyzed selective C–F bond functionalization. (submitted)

79.) Yang, K.; Yuan, D.; Herington, F.; Ge, H.-B.* Removable Template-Assisted Transition Metal-Catalyzed Distal C–H Functionalization. In 'Directed C-H Bond Functionalization: Concepts and Applications'. (accepted)

78.) Ge, R.; Yang, K.; Ge, H.-B.* Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles. In 'Functionalisation of Heterocycles through Transition Metal Catalyzed C-H Activation. (accepted)

77.) Liu, C.; Ge, R.; Chen, J.; Guo, H.-M.; Bartholomore, T.; Maiti, D.* Ge, H.-B.* Facile Construction of Distal and Diversified Tertiary and Quaternary Stereocenters. The Proceedings of the National Academy of Sciences 2024, DOI:10.1073/pnas.2408541121

76.) Liu, C.; Wang, L.; Ge, H.-B.* Multifunctionalization of Alkenyl Alcohols via a Sequential Relay Process. Journal of the American Chemical Society 2024, DOI: 10.1021/jacs.4c09522

75.) Pradhan, S.; Dutta, U.; Biswas, J. P.; Elsaid, M.; Ge, H.-B.* Maiti, D.* Palladium-Catalyzed Para-Selective Arylation of 1-Naphthamide. Organic Letters 2024, DOI: 10.1021/acs.orglett.4c04104

74.) Li, Q.; Yuan, D.; Liu, C.; Herington, F.; Yang, K.; Ge, H.-B.* An Environmentally Friendly Method for Oxidation of Sulfides. Molecules 2024, DOI:10.3390/molecules29163899

73.) Dutta, B.; Mahajan, M.; Ghosh, A.; Dajek, M.; Kowalczyk, R.;* Mondal, B.;* Ge, H.-B.;* Zhang, X.-L.;* Maiti, D.* Hydrogen bonding template enables meta-C-H alkenylation of Nitroarenes. Nat. Commun. 2024, DOI: 10.1038/s41467-024-51764-1

72.) Zhang, J.X.; Sun, T.; Wang, K.-M.; Hu, R.-K.; Zhou, C.-L.; Ge, H.-B.* Li, B.-J.* Rh(III)-Catalyzed Build-Up Fused Heterocyclic Cations: Facile Access to White-Light-Emitting Materials. Chem. Sci. 2024, DOI: 10.1039/D4SC02188F

71.) Pal, T.; Ghosh, P.; Islam, M.; Guin, S.; Maji, S.; Dutta, S.; Das, J.; Ge, H.-B.;* Maiti, D.* Tandem dehydrogenation-olefination -decarboxylation of cycloalkyl carboxylic acids via multifold C-H activation. Nat. Commun. 2024, DOI: 10.1038/s41467-024-49359-x

70.) Ge, R.; Xu, Z.-T.; Yang, K.;* Ge, H.-B.* Transition Metal-Catalyzed C(sp3)–H Bond Fluorination Reactions. Chem. Catal. 2024, DOI: 10.1016/j.checat.2024.101009

69.) Xu, Z.; Li, Z.; Liu, C.; Yang, K.; Ge, H. Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands. Molecules 2024, 29, 259. DOI: 10.3390/molecules29010259

68.) Das, J.; Ali, W.; Ghosh, A.; Pal, T.; Mandal, A.; Teja, C.; Dutta, S.; Pothikumar, R.; Ge, H.-B.;* Zhang, X.-L.;* Maiti, D.* Access to Unsaturated Bicyclic Lactones by Overriding Conventional C(sp3)‒H Site Selectivity. Synform 2024, DOI: 10.1055/s-0040-1720627

67.) Bhattacharya, T.; Ghosh, S.; Dutta, S.; Guin, S.; Ge, H.-B.;* Sunoj, R. B.;* Maiti, D.* Combinatorial Ligand Assisted Simultaneous Control of Axial and Central Chirality in Highly Stereoselective C-H Allylation. Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202310112

66.) Das, J.; Ali, W.; Ghosh, A.; Pal, T.; Mandal, A.; Teja, C.; Dutta, S.; Pothikumar, R.; Ge, H.-B.;* Zhang, X.-L.;* Maiti, D.* Access to Unsaturated Bicyclic Lactones by Overriding Conventional C(sp3)‒H Site Selectivity. Nat. Chem, 2023, doi: 0.1038/s41557-023-01295-x.

65.) Elsaid, M.;† Ge, R.;† Liu, C.; Maiti, D.* Ge, H.-B.* Site-Selective C-H Functionalization of Carbazoles. Angew. Chem. Int. Ed. 2023, doi: 10.1002/anie.202303110 (†equal contribution).

64.) Wajid Ali, W.; Saha, A. Ge, H.-B.;* Maiti, D.* Photoinduced meta-Selective C−H Oxygenation of Arenes. JACS, Au 2023, 3, 1790-1799.

63.) Ge, R.; Herington, F.; Mangawang, A.; Maiti, D.* Ge, H.-B.* Palladium-Catalyzed Cascade Reactions Initiated with Directed Activation of Unactivated sp3 C−H Bonds. Tetrahedron Chem, 2023, doi: 10.1016/j.tchem.2023.100046.

62.) Yang, K.; Ge, H.-B.* Pd(II)-catalyzed ligand-promoted γ-C(sp2)‒H arylation of free allylamines. Chem Catal, 2023, doi: 10.1016/j.checat.2023.100818

61.) Ge, H.-B.* Distal Functionalization via Transition Metal Catalysis. Chem. Proc, 2022, 12, 7-9.

60.) Xiong, H. Y.; Zhang, G.; Elsaid, M.; Ge, H.-B.* Ag, Au, and Pt-Catalyzed C−H Functionalization. In 'Handbook of CH-Functionalization'. 2022, in press, DOI: 10.1002/9783527834242 .

59.) Yang, K.; Li, Z.; Hu, Q.; Elsaid, M.; Liu, C.; Chen, J.; Ge, H. Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles. Catalysts 2022, 12, 1163

58.) Tang, L.; Hu, Q.; Yang, K.; Elsaid, M.; Liu, H.; Ge, H. Recent advances in direct α-C(sp3)−H bond functionalization of thioethers. Green Synthesis and Catalysis 2022, 3, 203-211.

57.) Yang, K.; Li, Z.; Liu, C.; Li, Y.; Hu, Q.; Elsaid, M.; Li, B.; Das, J.; Dang, Y.; Maiti, D.; Ge, H. Ligand-promoted palladium-catalyzed β-methylene C−H arylation of primary aldehydes. Chem. Sci. 2022, 13, 5938-5943.

56.) Li, B.; Elsaid, M.; Ge, H. Transition Metal-Catalyzed Site-Selective γ- and δ-C(sp3)-H Functionalization Reactions. Chem. 2022, 8, 1254-1360.

55.) Wang, K.; Zhang, J.; Hu, R.; Liu, C.; Bartholome, T. A.; Ge, H.; Li, B. Transition Metal-Catalyzed C−C Bond-Forming Reactions via C−H Activation for the Development of Fluorescent Materials with Practical Values. ACS Catal. 2022, 12, 2796–2820.

54.) Chandrashekar, H. B.; Dolui, P.; Li, B.; Mandal, A.; Liu, H.; Guin, S.; Ge, H.; Maiti, D. Ligand-Enabled δ-C(sp3)−H Borylation of Aliphatic Amines. Angew. Chem. 2021, 60, 18194-18200.

53.) Yang, K.; Song, M.; Liu, H.; Ge, H. Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy. Chem. Sci. 2020, 11, 12616-12632.

52.) Li, B.; Ali, A. I. M.; Ge, H. Recent Advances in Using Transition-Metal-Catalyzed C–H Functionalization to Build Fluorescent Materials.” Chem. 2020, 6, 2591–2657.

51.) Yang, K.; Song, M.; Ali, A. I. M.; Mudassir, S. M.; Ge, H. Recent Advances in the Application of Selectfluor as a "Fluorine-free" Functional Reagent in Organic Synthesis. Chem Asian J. 2020, 15, 729-741.

50.) Li, B.; Lawrence, B.; Li, G.; Ge, H. Ligand-Controlled Direct gamma-C-H Arylation of Aldehydes. Angew. Chem. 2020, 59, 3078-3082.

49.) Yang, K.; Niu, B.; Ma, Z.; Wang, H.; Lawrence, B.; Ge, H. Silver-Promoted Site-Selective Intramolecular Cyclization of 2-Methylthiobenzamide Through alpha-C(sp(3))-H Functionalization. J. Org. Chem. 2019, 84, 14045-14052.

48.) Niu, B.; Yang, K.; Lawrence, B.; Ge, H. Transient Ligand-Enabled Transition Metal-Catalyzed C-H Functionalization. ChemSusChem. 2019, 12, 2955-2969.

47.) Li, B.; Ge, H. Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials. Sci. Adv. 2019, 5, 5.

46.) Zhang, Y.; Li, Z.; Ge, H.; Zhu, X.; Zhao, Z. Dual hepatocyte-targeting fluorescent probe with high sensitivity to tumorous pH: Precise detection of hepatocellular carcinoma cells. Sens. Actuators. 2019, 285, 584-589.

45.) Yang, K.; Zhang, H.; Niu, B.; Tang, T.; Ge, H. Benzisothiazol-3-ones through a Metal-Free Intramolecular N-S Bond Formation. Eur. J. Org. Chem. 2018, 40, 5520-5523.

44.) Li, B.; Seth, K.; Niu, B.; Pan, L.; Yang, H.; Ge, H. Transient-Ligand-Enabled ortho-Arylation of Five-Membered Heterocycles: Facile Access to Mechanochromic Materials. Angewandte Chemie. 2018, 57, 3401-3405.

43.) Pan, L.; Yang, K.; Li, G.; Ge, H. Palladium-catalyzed site-selective arylation of aliphatic ketones enabled by a transient ligand. Chem. Commun. 2018, 54, 2759-2762.

42.) Mei, Y.; Ye, Q.; Yang, B.; Xiao, L.; Ge, H. Novel synthesis method of ataluren. From Faming Zhuanli Shenqing (2017), CN 106279057 A 20170104.

41.) Ye, Q.; Ge, H.; Mei, Y.; Xiao, L. Process for synthesizing fingolimod. From Faming Zhuanli Shenqing (2017), CN 106397224 A 20170215.

40.) Liu, Y.; Ge, H. Site-selective C-H arylation of primary aliphatic amines enabled by a catalytic transient directing group. Nat. Chem. 2017, 9, 26-32.

39.) Yang, K.; Li, Q.; Liu, Y.; Li, G.; Ge, H. Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand. Synform. 2016, DOI: 10.1055/s-0036-1589706

38.) Yang, K.; Li, Q.; Liu, Y.; Li, G.; Ge, H. Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand. J. Am. Chem. Soc. 2016, 138, 12775-12778.

37.) Wu, X.; Miao, J.; Li, Y.; Li, G.; Ge, H. Copper-promoted site-selective carbonylation of sp(3) and sp(2) C-H bonds with nitromethane. Chem. Sci. 2016, 7, 5260-5264.

36.) Liu, Y.; Yang, K.; Ge, H. Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))-H bonds with acetonitrile. Chem. Sci. 2016, 7, 2804-2808.

35.) Miao, J.; Fang, P.; Jagdeep, S.; Ge, H. Palladium-catalyzed decarboxylative alkoxycarbonylation of potassium aryltrifluoroborates with potassium oxalate monoesters. Org. Chem. Front. 2016, 3, 243-250.

34.) Miao, J.; Ge, H. Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Coupling of C(sp(3))-H Bonds. Eur. J. Org. Chem. 2015, 2015, 7859-7868.

33.) Zhao, W.; Xie, P.; Bian, Z.; Zhou, A.; Ge, H. Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process. J. Org. Chem. 2015, 80, 9167-9175.

32.) Miao, J.; Yang, K.; Kurek, M.; Ge, H. Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp(3))-H Bonds. Org. Lett. 2015, 17, 3738-3741.

31.) Niu, B.; Zhao, W.; Ding, Y.; Bian, Z.; Pittman, C. U. Jr.; Ge, H. Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp(3))-H Functionalization. J. Org. Chem. 2015, 80, 7251-7257.

30) Wu, X.; Zhao, Y.; Ge, H. Direct Aerobic Carbonylation of C(sp(2))-H and C(sp(3))-H Bonds through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source. J. Am. Chem. Soc. 2015, 137, 4924-4927.

29.) Wu, X.; Yang, K.; Zhao, Y.; Sun, H.; Li, G.; Ge, H. Cobalt-catalysed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp(3) carbons. Nat. Comm. 2015, 6, 6462.

41467_2015_Article_BFncomms7462_Fig1_HTM

28.) Wu, X.; Wang, M.; Zhang, G.; Zhao, Y.; Wang, J.; Ge, H. Copper-catalyzed diastereoselective aerobic intramolecular dehydrogenative coupling of hydrazones via sp(3) C-H functionalization. Chem. Sci. 2015, 6, 5882-5890.

27.) Wu, X.; Zhao, Y.; Ge, H. Pyridine-enabled copper-promoted cross dehydrogenative coupling of C(sp(2))-H and unactivated C(sp(3))-H bonds. Chem. Sci. 2015, 6, 5978-5983.

26.) Zhao, W.; Xie, P.; Bian, Z.; Zhou, A.; Ge, H.; Niu, B.; Ding, Y. Generation of ArS-substituted flavone derivatives using aryl thiols as sulfenylating agents. RSC Adv. 2015, 5, 59861-59864.

25.) Wu, X,; Zhao, Y.; Ge, H. Copper-Promoted Site-Selective Acyloxylation of Unactivated C(sp(3))-H Bonds. Chem Asian J. 2014, 9, 2736-2739.

24.) Miao, J.; Richards, N. G. J.; Ge, H. Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides. Chem. Commun. 2014, 50, 9687-9689.

23.) Wu, X.; Zhao, Y.; Ge, H. Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp(3))-H Bonds. Chem. - Eur. J. 2014, 20, 9530-9533.

22.) Yang, K.; Zhang, C.; Wang, P.; Zhang, Y.; Ge, H. Nickel-Catalyzed Decarboxylative Acylation of Heteroarenes by sp(2) C-H Functionalization. Chem. - Eur. J. 2014, 20, 7241-7244.

21.) Miao, J.; Ge, H. Palladium-Catalyzed Decarboxylative Cross-Coupling of alpha-Oxocarboxylic Acids and Their Derivatives. Synlett. 2014, 25, 911-919.

20.) Wu, X.; Zhao, Y.; Zhang, G.; Ge, H. Copper-Catalyzed Site-Selective Intramolecular Amidation of Unactivated C( sp3) - H Bonds. Angew. Chem. 2014, 53, 3706-3710.

19.) Wu, X.; Zhao, Y.; Ge, H. Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp(3))-H Bonds. J. Am. Chem. Soc. 2014, 136, 1789-1792.

18.) Wu, X.-S.; Zhao, Y.; Ge, H.-B. Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp3 )–H Bonds, Synform, 2014, DOI: 10.1055/s-0033-1341123

17.) Miao, J.; Ge, H. Palladium-Catalyzed Chemoselective Decarboxylative Ortho Acylation of Benzoic Acids with alpha-Oxocarboxylic Acids. Org. Lett. 2013, 15, 2930-2933.

16.) Zhang, G.; Zhao, Y.; Ge, H. Copper-Catalyzed Aerobic Intramolecular Dehydrogenative Cyclization of N,N-Disubstituted Hydrazones through C-sp3-H Functionalization. Angew. Chem. 2013, 52, 2559-2563.

15.) Zhang, G.; Miao, J.; Zhao, Y.; Ge, H. Copper-Catalyzed Aerobic Dehydrogenative Cyclization of N-Methyl-N-phenylhydrazones: Synthesis of Cinnolines. Angew. Chem. 2012, 51, 8318-8321.

14.) Wang, C.; Ge, H. Silanol as a Removable Directing Group for the Pd-II-Catalyzed Direct Olefination of Arenes. Chem. - Eur. J. 2011, 17, 14371-14374.

13.) Li, M.; Wang, C.; Ge, H. Pd(II)-Catalyzed Decarboxylative Cross-Coupling of Potassium Aryltrifluoroborates with alpha-Oxocarboxylic Acids at Room Temperature. Org. Lett. 2011, 13, 2062-2064.

12.) Li, M.; Wang, C.; Fang, P.; Ge, H. Pd(ii)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions. Chem. Comm. 2011, 47, 6587-6589.

11.) Wang, C.; Ge, H. Palladium-Mediated Olefination of 2-(tert-Butyldimethylsilyl)Pyridine via sp3 C-H Activation. Synthesis, 2011, 16, 2690-2594.

10.) Li, M.; Li, L.; Ge, H. Direct C-3-Alkenylation of Quinolones via Palladium-Catalyzed C-H Functionalization. Adv. Synth. Catal. 2010, 352, 2445-2449.

9.) Fang, P.; Li, M.; Ge, H. Room Temperature Palladium-Catalyzed Decarboxylative ortho-Acylation of Acetanilides with alpha-Oxocarboxylic Acids. J. Am. Chem. Soc. 2010, 132, 11898-11899.

8.) Li, M.; Ge, H. Decarboxylative Acylation of Arenes with alpha-Oxocarboxylic Acids via Palladium-Catalyzed C-H Activation. Org. Lett. 2010, 12, 3464-3467.

7.) Ge, H.-B.; Niphakis, M. J.; Georg, G. I. Palladium (II)-Catalyzed Direct Arylation of Enaminones using Organotrifluoroborates. J. Am. Chem. Soc. 2008, 130, 3708-3709.

6.) Ge, H.-B.; Wang, J.; Kayser, M.; Himes, R. H.; Georg, G. I. Synthesis, Tubulin Assembly, and Antiproliferative Activity of 10-O-Acetyl-5′-Hydroxybutitaxel. Bioorg. Med. Chem. Lett, 2008, 18, 6165-6167.

5.) Turunen, B. J.; Ge, H.-B.; Oyetunji, J.; Vasandani, V.; Desino, K.; Audus, K. L.; Himes, R. H.; Georg, G. I. Paclitaxel Succinate Analogues: Anionic and Amide Introduction As A Strategy to Impart Blood-Brain Barrier Permeability. Bioorg. Med. Chem. Lett, 2008, 18, 5971-5974.

4.) Peng, Y.-L.; Li, Q.; Liu, X.-G.; Yang, X.-L.; Ge, H.-B.; Chen, X.-F. “A New Method for The Preparation of Methyl tri-O-Benzoyl-4-deoxy-4-fluoro-a-D-glucopyranoside. CN 101245086, 2008.

3.) Ge, H.-B.; Spletstoser, J. T.; Yang, Y.; Kayser, M.; Georg, G. I. Synthesis of Docetaxel and Butitaxel Analogues through Kinetic Resolution of Racemic b-Lactams with 7-O-Triethylsilylbaccatin III. J. Org. Chem, 2007, 72, 756-759.

2.) Ge, H.-B.; Vasandani, V.; Huff, J. K.; Audus, K. L.; Himes, R. H.; Seelig, A.; Georg, G. I. Synthesis and interactions of 7-deoxy-, 10-deacetoxy- and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells. Bioorg. Med. Chem. Lett, 2006, 16, 433-436

1.) Ge, H.-B.; Zhu, X.; Wang, E.-H. Advances in Study of Thiazolidinedione Derivatives As Insulin Sensitizers. Prog. Pharma. Sci. 2001, 25, 31-35.